Our publications


Below you find a list of the key publications from our joint research

Artegiani B*,#, Hendriks D*,#.
*Equal contribution, #Corresponding author

Organoids from pluripotent stem cells and human tissues: When two cultures meet each other

Developmental Cell, 2025

Pagliaro A$, Andreatta F$, Finger R$, Artegiani B*,#, Hendriks D*,#.

$Co-first author
*Equal contribution, #Corresponding author

Generation of human fetal brain organoids and their CRISPR engineering for brain tumor modeling

Nature Protocols, 2025

Pagliaro A, Artegiani B*,#, Hendriks D*,#.

*Equal contribution, #Corresponding author

Emerging approaches to enhance human brain organoid physiology

Trends in Cell Biology, 2025

Hendriks D*,#, Artegiani B*,#, Margaritis T, Zoutendijk I, Chuva de Sousa Lopes S, Clevers H#.

*Equal contribution, #Corresponding author

Mapping of mitogen and metabolic sensitivity in organoids defines requirements for human hepatocyte growth.

Nature Communications, 2024.

Hendriks D*,#, Pagliaro A$, Andreatta F$, Ma Z, van Giessen J, Massalini S, López-Iglesias C, van Son G, DeMartino J, Damen M, Zoutendijk I, Staliarova N, Bredenoord A, Holstege F, Peters P, Margaritis T, Chuva de Sousa Lopes S, Wu W, Clevers H*,#, Artegiani B*,#.

$Co-second author
*Senior author, #Corresponding author

Human fetal brain self-organizes into long-term expanding organoids.

Cell, 2024.

Pagliaro A, Finger R, Zoutendijk I, Bunschuh S, Clevers H, Hendriks D*,#, Artegiani B*,#.

*Co-last author, #Corresponding author

Temporal morphogen gradient-driven neural induction shapes single expanded neuroepithelium brain organoids with enhanced cortical identity.

Nature Communications, 2023.

Rüland L, Andreatta F, Massalini S, Chuva de Sousa Lopes S, Clevers H, Hendriks D*,#, Artegiani B*,#.                                

*Co-last author, #Corresponding author

Organoid models of fibrolamellar carcinoma mutations reveal hepatocyte trans-differentiation through cooperative BAP1 and PRKAR2A loss.

Nature Communications, 2023.

Hendriks D#, Brouwers J, Hamer K, Geurts M, Luciana L, Massalini S, López-Iglesias C, Peters P, Rodríguez-Colman M, Chuva de Sousa Lopes S, Artegiani B*,#, Clevers H*,#.

*Co-last author, #Corresponding author

Engineered human hepatocyte organoids enable CRISPR-based target discovery and drug screening for steatosis.          
     
Nature Biotechnology, 2023.

Hendriks D*,#, Artegiani B*,#, Hu H, Chuva de Sousa Lopes S, Clevers H.  

*Co-first author, #Corresponding author   

Establishment of human fetal hepatocyte organoids and CRISPR-Cas9-based gene knockin and knockout organoid cultures from human liver.
     
Nature Protocols, 2021.

Hendriks D, Clevers H, Artegiani B.     

CRISPR-Cas tools and their application in genetic engineering of human stem cells and organoids.   
     
Cell Stem Cell, 2020.

Artegiani B*, Hendriks D*, Beumer J, Kok R, Zheng X, Joore I, Chuva de Sousa Lopes S, van Zon J, Tans S, Clevers H.

*Co-first author

Fast and efficient generation of knock-in human organoids using homology-independent CRISPR-Cas9 precision genome editing.          
     
Nature Cell Biology, 2020.